CD 2 Regulates the Positive Selection and Function of Antigen - Specific CD 4 Ï CD 8 " T Cells
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چکیده
The CD2 glycoprotein has been implicated in both positive ment of positive selection, the lack of CD2 was associated and negative regulation of T-cell mitogenesis. To study the with defects in proliferative responses and interferon-g proinvolvement of CD2 in T-lymphocyte development and imduction when transgenic thymocytes and mature T lymphomune responses, we have analyzed two lines of CD2-null cytes were stimulated with the appropriate antigens. These mice, each expressing a distinct class I major histocompatifindings raise the possibility that impaired sensitivity to sebility complex (MHC)-restricted T-cell receptor (TCR). In both lecting ligands in the thymus may provide a selective advansituations, the absence of CD2 appeared to promote the postage that improves the efficiency of positive selection for itive selection of cells in a manner that is similar to that certain TCRs. Furthermore, the results highlight the potenwhich occurs in the absence of CD5. Consistent with this, tial for a differential role for CD2 in thymocyte selection and compound homozygotes that lacked both CD2 and CD5 T-cell immune responses. showed evidence of enhanced positive selection even in the q 1997 by The American Society of Hematology. absence of a transgenic TCR. Despite the observed enhance-
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تاریخ انتشار 1997